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    William Dalrymple (historian)

    AM-2232
    Legal status
    Legal status
    Identifiers
    • 5-(3-(1-Naphthoyl)-1H-indol-1-yl)pentanenitrile
    CAS Number
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC24H20N2O
    Molar mass352.437 g·mol−1
    3D model (JSmol)
    • c1ccc2c(c1)cccc2C(=O)c3cn(c4c3cccc4)CCCCC#N
    • InChI=1S/C24H20N2O/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,16H2 ☒N
    • Key:VWVAIBKHFCUSMD-UHFFFAOYSA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    AM-2232 (1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole) is a drug that acts as a potent but unselective agonist for the cannabinoid receptors, with a Ki of 0.28 nM at CB1 and 1.48 nM at CB2.[1][2]

    In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-2232 are Schedule I Controlled Substances.[3]

    See also

    References

    1. ^ US patent 7241799, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2007-07-10 
    2. ^ Zagzoog A, Brandt AL, Black T, Kim ED, Burkart R, Patel M, Jin Z, Nikolaeva M, Laprairie RB (May 2021). "Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor". Scientific Reports. 11 (1): 10611. doi:10.1038/s41598-021-90167-w. PMC 8134483. PMID 34012003.
    3. ^ 21 U.S.C. § 812: Schedules of controlled substances


    Credit: Wikipedia https://en.wikipedia.org/wiki/AM-2232

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