Not logged in | Create account | Login
    Menu

      Authorpædia Trademarks

      Social buttons

      Languages

      Read

      AUTHORPÆDIA is hosted by Authorpædia Foundation, Inc. a U.S. non-profit organization.

    Tobias Barreto

    This article is about the drug. For the Roman province, see Tripolitania. For the city, see Tripoli.
    Triprolidine
    Clinical data
    Trade namesFlonase Nighttime Allergy Relief, Actidil, others
    AHFS/Drugs.comMonograph
    Pregnancy
    category
    • C (US)
    Routes of
    administration    		By mouth
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    BioavailabilityOral: 4%
    Protein binding90%
    MetabolismHepatic (CYP2D6)
    Elimination half-life4–6 hours
    ExcretionRenal
    Identifiers
    • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
      prop-1-enyl]pyridine
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.006.934 Edit this at Wikidata
    Chemical and physical data
    FormulaC19H22N2
    Molar mass278.399 g·mol−1
    3D model (JSmol)
    Melting point60 °C (140 °F)
    Solubility in water500 mg/mL (20 °C)
    • n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3
    • InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ checkY
    • Key:CBEQULMOCCWAQT-WOJGMQOQSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]

    Today, triprolidine is used less frequently and has been replaced in popular medications by other antihistamines like diphenhydramine, promethazine, chlorpheniramine, as well as second-generation antihistamines like loratadine and fexofenadine. Triprolidine remains an ingredient in the cold medicine Actifed in many territories.[citation needed]

    It was patented in 1948 and came into medical use in 1953.[3]

    See also

    References

    1. ^ a b Goldsmith P, Dowd PM (January 1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic Clinics. 11 (1): 87–95. doi:10.1016/S0733-8635(18)30285-7. PMID 8094649.
    2. ^ Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical Pharmacy. 3 (6): 638–43. PMID 6509877.
    3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
    Credit: Wikipedia https://en.wikipedia.org/wiki/Triprolidine

    Explore other authors