Mikhail Gorbachev

SLC6A9
Identifiers
Aliases	SLC6A9, GLYT1, Glycine transporter 1, solute carrier family 6 member 9, GCENSG
External IDs	OMIM: 601019; MGI: 95760; HomoloGene: 5050; GeneCards: SLC6A9; OMA:SLC6A9 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	44,031,467 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	117,732,395 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	6536
	14664
	ENSG00000196517
	ENSMUSG00000028542
	P48067
	P28571
NM_001024845; NM_001261380; NM_006934; NM_201649; NM_001328626;
	NM_001328627; NM_001328628; NM_001328629; NM_001328630
	NM_008135; NM_001355175; NM_001369016; NM_001369017
NP_001020016; NP_001248309; NP_001315555; NP_001315556; NP_001315557;
	NP_001315558; NP_001315559; NP_008865; NP_964012
	NP_032161; NP_001342104; NP_001355945; NP_001355946
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium- and chloride-dependent glycine transporter 1, also known as glycine transporter 1, is a protein that in humans is encoded by the SLC6A9 gene which is promising therapeutic target for treatment of diabetes and obesity. ^[5]^[6]^[7]^[8]

Selective inhibitors

Elevation of extracellular synaptic glycine concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders. Several drug candidates have reached clinical trials.^[9]

ASP2535^[10]
Bitopertin (RG1678), which has entered phase II trials for the treatment of schizophrenia^[11]
Iclepertin (BI 425809) by Boehringer Ingelheim which is thought to improve cognitive impairment due to schizophrenia
Org 25935 (Sch 900435)
PF-03463275 (in phase II trial)
Pesampator (PF-04958242) by Pfizer
Sarcosine which is thought to improve cognitive impairment due to schizophrenia

Pathological mutations

Mutations of the gene may cause a severe metabolic disorder discovered in 2016 and called glycine encephalopathy with normal serum glycine (OMIM 617301), also known as GlyT1 encephalopathy.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196517 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sinha JK, Durgvanshi S, Verma M, Ghosh S (June 2023). "Investigation of SLC6A9 and SLC5A1 as a promising therapeutic target for obesity and diabetes using in silico characterization, 3D structure prediction and molecular docking analysis". Alzheimer's & Dementia. 19 (S1). doi:10.1002/alz.064229. ISSN 1552-5260.
^ Kim KM, Kingsmore SF, Han H, Yang-Feng TL, Godinot N, Seldin MF, et al. (April 1994). "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes". Molecular Pharmacology. 45 (4): 608–617. doi:10.1016/S0026-895X(25)10145-4. PMID 8183239.
^ Jones EM, Fernald A, Bell GI, Le Beau MM (Nov 1995). "Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization". Cytogenetics and Cell Genetics. 71 (3): 211. doi:10.1159/000134110. PMID 7587377.
^ "Entrez Gene: SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9".
^ Harvey RJ, Yee BK (November 2013). "Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain". Nature Reviews. Drug Discovery. 12 (11): 866–885. doi:10.1038/nrd3893. PMID 24172334. S2CID 28022131.
^ Harada K, Nakato K, Yarimizu J, Yamazaki M, Morita M, Takahashi S, et al. (June 2012). "A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease". European Journal of Pharmacology. 685 (1–3): 59–69. doi:10.1016/j.ejphar.2012.04.013. PMID 22542656.
^ Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, et al. (June 2010). "Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia". Journal of Medicinal Chemistry. 53 (12): 4603–4614. doi:10.1021/jm100210p. PMID 20491477.

Olivares L, Aragón C, Giménez C, Zafra F (April 1995). "The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter". The Journal of Biological Chemistry. 270 (16): 9437–9442. doi:10.1074/jbc.270.16.9437. PMID 7721869.
Borowsky B, Mezey E, Hoffman BJ (May 1993). "Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene". Neuron. 10 (5): 851–863. doi:10.1016/0896-6273(93)90201-2. PMID 8494645. S2CID 24224402.
Evans J, Herdon H, Cairns W, O'Brien E, Chapman C, Terrett J, et al. (December 1999). "Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter". FEBS Letters. 463 (3): 301–306. Bibcode:1999FEBSL.463..301E. doi:10.1016/S0014-5793(99)01636-1. PMID 10606742. S2CID 21445629.
Hanley JG, Jones EM, Moss SJ (January 2000). "GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1". The Journal of Biological Chemistry. 275 (2): 840–846. doi:10.1074/jbc.275.2.840. PMID 10625616.
Geerlings A, López-Corcuera B, Aragón C (March 2000). "Characterization of the interactions between the glycine transporters GLYT1 and GLYT2 and the SNARE protein syntaxin 1A". FEBS Letters. 470 (1): 51–54. Bibcode:2000FEBSL.470...51G. doi:10.1016/S0014-5793(00)01297-7. PMID 10722844. S2CID 46670631.
Christie GR, Ford D, Howard A, Clark MA, Hirst BH (February 2001). "Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1". Gastroenterology. 120 (2): 439–448. doi:10.1053/gast.2001.21207. PMID 11159884.
Reye P, Penfold P, Pow DV (June 2001). "Glyt-1 expression in cultured human Müller cells and intact retinae". Glia. 34 (4): 311–315. doi:10.1002/glia.1064. PMID 11360303. S2CID 39431701.
Geerlings A, Núñez E, Rodenstein L, López-Corcuera B, Aragón C (July 2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells". Journal of Neurochemistry. 82 (1): 58–65. doi:10.1046/j.1471-4159.2002.00930.x. PMID 12091465.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Antonov SM, Brovtsyna NB, Mironova EV (2005). "The mechanism of allosteric interaction of cytoplasmic and extracellular Cl- in the glial glycine transporter (hGlyTlb)". Doklady Biological Sciences. 402 (1–6): 163–166. doi:10.1007/s10630-005-0076-z. PMID 16121932. S2CID 19628294.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196517 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Sinha JK, Durgvanshi S, Verma M, Ghosh S (June 2023). "Investigation of SLC6A9 and SLC5A1 as a promising therapeutic target for obesity and diabetes using in silico characterization, 3D structure prediction and molecular docking analysis". Alzheimer's & Dementia. 19 (S1). doi:10.1002/alz.064229. ISSN 1552-5260.

[pmid8183239-6] Kim KM, Kingsmore SF, Han H, Yang-Feng TL, Godinot N, Seldin MF, et al. (April 1994). "Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes". Molecular Pharmacology. 45 (4): 608–617. doi:10.1016/S0026-895X(25)10145-4. PMID 8183239.

[pmid7587377-7] Jones EM, Fernald A, Bell GI, Le Beau MM (Nov 1995). "Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization". Cytogenetics and Cell Genetics. 71 (3): 211. doi:10.1159/000134110. PMID 7587377.

[entrez-8] "Entrez Gene: SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9".

[9] Harvey RJ, Yee BK (November 2013). "Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain". Nature Reviews. Drug Discovery. 12 (11): 866–885. doi:10.1038/nrd3893. PMID 24172334. S2CID 28022131.

[10] Harada K, Nakato K, Yarimizu J, Yamazaki M, Morita M, Takahashi S, et al. (June 2012). "A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease". European Journal of Pharmacology. 685 (1–3): 59–69. doi:10.1016/j.ejphar.2012.04.013. PMID 22542656.

[pmid20491477-11] Pinard E, Alanine A, Alberati D, Bender M, Borroni E, Bourdeaux P, et al. (June 2010). "Selective GlyT1 inhibitors: discovery of [4-(3-fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia". Journal of Medicinal Chemistry. 53 (12): 4603–4614. doi:10.1021/jm100210p. PMID 20491477.

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Mikhail Gorbachev

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